人才招聘
加入和铂，共同书写下一代抗体药物的未来。
1. 抗体偶联与表征分析
• 负责抗体-药物偶联物（ADC）的偶联反应操作，包括半胱氨酸偶联、糖基偶联及酶催化偶联等
• 偶联后产物的纯化
• 使用HIC-HPLC、RP-HPLC、SEC-HPLC对ADC进行纯度、DAR值、聚集度分析
2. 体外药效与功能评价
• 体外细胞杀伤实验
• 利用流式进行抗体/ADC的靶细胞结合实验
3. 实验记录与报告
• 规范撰写实验记录，确保数据可追溯
• 数据分析与结果汇总，撰写实验报告
学历与经验
• 生物化学、细胞生物学、分子生物学或相关专业，硕士及以上学历
实验技能
• 熟悉HPLC操作与分析（HIC、SEC、RP）
• 熟悉SDS-PAGE等常规生化分析
• 具备哺乳动物细胞培养经验者优先
综合素质
• 严谨的实验操作习惯，注重细节
• 良好的数据分析和问题解决能力
• 具备团队协作精神和沟通能力
• 英文文献阅读能力
Seeking an accomplished scientist and drug discovery leader with deep expertise in the cardiometabolic therapeutic area, particularly obesity, metabolic diseases, and cardiovascular risk reduction. The successful candidate will possess a strong foundation in drug discovery and translational development, with a demonstrated track record of advancing innovative therapeutic programs from target validation through clinical candidate selection.
The ideal candidate will have extensive experience leading complex discovery programs through cross-functional internal teams and external collaborations, driving scientific strategy, execution, timelines, and critical decision-making across the development continuum. This individual will serve as a key scientific leader, integrating disease biology, therapeutic innovation, and portfolio strategy to accelerate the advancement of novel cardiometabolic therapies.
PhD, MD, or equivalent advanced scientific training in a relevant discipline.
Minimum of 8 years of industry experience, including experience within both leading pharmaceutical and biotechnology organizations.
Deep understanding of drug discovery and development principles, including target identification, validation, lead optimization, translational research, and candidate selection.
Demonstrated success leading multidisciplinary teams and managing strategic external partnerships.
Scientific and technical expertise in next-generation therapeutic modalities, including:
siRNA and RNA-based therapeutics
Gene modulation and genetic medicine platforms
Targeted delivery technologies
Antibody-Oligonucleotide Conjugates (AOCs)
Antibody-Peptide/Payload Conjugates (APCs)
Other emerging precision medicine approaches
Strong leadership, communication, and stakeholder management skills, with the ability to influence strategy across diverse scientific and business functions.
The successful candidate will combine scientific excellence, strategic vision, and operational rigor to drive the discovery and development of transformative therapies for patients with cardiometabolic diseases.
Experienced drug discovery leader with deep expertise in cardiometabolic diseases, including obesity and cardiovascular risk reduction, and a proven ability to advance innovative programs from discovery through development. Requires at least 5 years of industry experience across leading pharmaceutical and biotechnology organizations, with demonstrated leadership of cross-functional teams and external partnerships. Expertise in RNA therapeutics, gene modulation, antibody conjugates (AOC/APC), and other next-generation therapeutic modalities is highly desirable. PhD, MD, or equivalent advanced degree preferred.
Seeking an accomplished scientist with a strong background in oligonucleotide and pharmaceutical chemistry, and deep expertise in siRNA design, chemical modification, conjugation technologies, and delivery platform innovation. The candidate should have a proven track record in developing proprietary siRNA platforms for cardiometabolic drug discovery, with experience targeting both hepatic and extrahepatic tissues.
The ideal candidate will bring substantial hands-on experience in advancing RNA therapeutic programs from discovery through candidate nomination, including leadership of cross-functional internal teams, external partnerships, project timelines, and key development milestones. A demonstrated ability to integrate scientific excellence with strategic execution is essential.
PhD or equivalent advanced training in chemistry, pharmaceutical sciences, oligonucleotide therapeutics, or a related discipline.
Minimum of 5 years of industry experience within leading siRNA or RNA therapeutics biotechnology companies.
Deep expertise in siRNA chemistry, design, optimization, and platform development.
Strong experience developing proprietary technologies for liver and extrahepatic delivery of RNA therapeutics.
Hands-on knowledge of GalNAc conjugation and lipid nanoparticle (LNP) delivery systems.
Proven experience driving discovery programs through effective management of internal and external collaborations.
Preferred expertise in emerging modalities and targeted delivery approaches, including:
Gene silencing and gene modulation technologies
Antibody-Oligonucleotide Conjugates (AOCs)
Antibody-Payload/Peptide Conjugates (APCs)
Other next-generation targeted delivery platforms
The successful candidate will combine scientific leadership, innovation, and executional rigor to advance a differentiated cardiometabolic RNA therapeutics pipeline and enable the discovery of transformative medicines for patients.
Experienced drug discovery leader with deep expertise in siRNA therapeutics, oligonucleotide chemistry, and delivery technologies, including GalNAc and LNP platforms. Proven track record in developing proprietary siRNA platforms for cardiometabolic diseases, spanning both hepatic and extrahepatic targets. Minimum 5 years of experience in RNA-focused biotechnology companies, with demonstrated success leading cross-functional teams, external collaborations, and discovery programs. Experience with gene modulation, AOCs, APCs, and other next-generation delivery modalities is highly desirable.
团队的科学与项目领导者，负责制定ADC项目的整体战略方向，并确保从分子设计到概念验证的顺利转化。需具备深厚的肿瘤生物学背景和ADC药物开发经验，能够独立领导项目，并与免疫学、药理学及CMC团队紧密协作。
• 科学领导与项目管理: 为Oncology团队的ADC项目提供科学指导和战略规划。主导项目从早期研发到候选化合物（PCC）确认阶段的推进，制定并管理项目时间线、关键里程碑和预算。作为项目负责人，协调内外部资源（包括CRO/CDMO），确保项目按时、高质量完成。
• 概念验证 (POC) 策略制定: 设计并监督体外和体内的概念验证实验。与In Vivo Pharmacology团队合作，制定PK/PD/efficacy研究策略，以验证ADC分子的作用机制（MOA）和治疗窗口。
• 跨部门协作: 作为肿瘤团队在项目核心团队中的主要代表，与CRO，项目合作方，以及Immunology、DMPK、临床前安全评价及CMC部门进行高效沟通，确保外包工作的质量和进度，整合各方数据，推动项目决策。
• 技术指导: 指导并培养团队中的Principal Scientists，在靶点验证、偶联策略选择、DAR优化等方面提供专业指导。
• 博士学位（PhD/MD），肿瘤生物学、生物化学或相关领域。
• 8年以上工业界经验，其中至少3年专注于ADC药物研发，并有成功推进项目进入IND或临床阶段的记录。
• 深刻理解ADC药物的作用机制，包括靶点选择、抗体工程、连接子/载荷技术及偶联化学。
• 优秀的项目管理能力和团队领导力，能够有效驱动跨功能团队。
• 熟悉临床前早期开发策略，包括PK，毒理，等影响因素。
We are seeking a highly motivated and innovative Principal Scientist to join our Immunology Discovery team. In this pivotal role, you will lead research efforts focused on understanding the complex crosstalk between non-immune cells (such as fibroblasts, epithelial, and endothelial cells) and the immune system, with specialized expertise in cell profiling, primary cell function and pharmacodynamic (PD) assay development, validation, and implementation. Your work will directly drive the discovery and development of novel therapeutics, including monoclonal antibodies, multi-specifics, and antibody-based modalities, targeting autoimmune, inflammatory, and fibrotic diseases.
As a subject matter expert in non-immune cell biology within an immunological context, you will spearhead target identification, validation, and the development of translational assays to advance our robust pipeline of next-generation immunotherapeutics.
• Assay Development: Design, optimize, and execute complex in vitro and ex vivo primary cell assays (e.g., co-culture systems, organoids) to model tissue-specific immune responses and evaluate the efficacy of novel biologics in vertical and parallel targeting strategies. Develop, validate and implement pharmacodynamic (PD) assay and analyze complicated data using specialized software and interpret results to generate data-driven scientific conclusions and actionable recommendations.
• Comprehensive profiling: apply advanced techniques (eg. Multi-color flow cytometry) to perform cell phenotyping, and functional analysis of various non-immune cell subsets from preclinical animal models and human samples.
• Methodology: establish and standardize SOPs for immunology and PD assays to ensure data accuracy, reproducibility, and lab efficiency.
• Scientific Leadership: Serve as the in-house expert on non-immune cell biology (stromal, epithelial, endothelial) and their role in immune regulation, tissue homeostasis, and pathology (e.g., fibrosis, chronic inflammation, allergy and autoimmunity).
• Prepare detailed scientific reports, study protocols, and regulatory documentation; present research findings to internal leadership, cross-functional teams, and external partners; contribute to scientific publications, conference presentations, and patent applications.
• Target Discovery & Validation: Identify and validate novel therapeutic targets that modulate stromal-immune or epithelial-immune interactions in autoimmune and fibrotic diseases (e.g., rheumatic diseases, pulmonary fibrosis).
• Mentorship: Manage, mentor, and develop a team of scientists and research associates, fostering a culture of scientific rigor and innovation.
• Internal collaboration: collaborate cross-functionally with drug discovery, preclinical development, clinical research, analytical development, and regulatory teams to align immunology strategies with overall program milestones, and support study design for preclinical and clinical trials.
• External Collaboration: Publish findings in peer-reviewed journals, present at major scientific conferences, and manage external collaborations with academic institutions and CROs.
• Pipeline Advancement: Represent the immunology function on cross-functional project teams, guiding programs from early discovery through IND-enabling studies.
• Education: Ph.D. degree in Immunology, Cell Biology, Molecular Biology, or a closely related biomedical science discipline, with formal specialized training in immunology.
• Experience: A minimum of 6-8+ years of post-doctoral industry experience in biotech or pharmaceutical drug discovery, with proven track record in immunology research and assay development
• Technical Expertise:
• Advanced proficiency in flow cytometry: multi-color panel design, instrument operation for both conventional and spectral flow cytometer, data acquisition, high-dimensional non-immune cell phenotyping, and functional cell analysis for diverse primary immune and non-immune cell populations.
• Non-Immune cell profiling using a range of other techniques including tissue sectioning, confocal microscopy, ELISA, MSD, Western Blot and PCR.
• Lead to project progression using primarily cell based screening and profiling assays to support validation and MOA studies including biomaterial development (human extracelluar matrix scaffords) from a range of tissues.
• Extensive experience in all stages of pharmacodynamic (PD) assay development, optimization, validation, and data analysis for preclinical and clinical research.
• Hands-on experience in primary non-immune cell isolation/purification using positive and negative selection strategies, differentiation, culture, stimulation, and functional characterization from human and animal samples.
• Extensive experience with non-immune cell line culture, complex 2D/3D co-culture models, flow cytometry (FACS), transcriptomics (e.g., scRNA-seq), and in vitro functional immunological assays.
• Design, develop and perform immunocytochemistry / immunofluorescence tissue staining and transcriptomics methods to support programs as they transition into the clinic. Analyse patient materials using the above methods internally and at CRO.
• Deep conceptual and practical knowledge of non-immune cell biology (e.g., fibroblasts, epithelial cells) and their interplay with innate and adaptive immune cells.
• Development, evaluation and implementation of new technologies as required by the projects.
• Proven aseptic technique, attention to detail and acts independently to determine methods and procedures on new or special assignments.
• Familiarity with therapeutic antibody discovery and advanced modalities (e.g., mAb, BsAb, TsAb, TCE, ADC, CAR-T and AOCs).
• Disease Area Knowledge: Proven track record in researching immunological and inflammatory diseases, fibrotic disorders, or auto-immune pathologies.
• Data & Analytical Skills: Strong quantitative data analysis skills, experience with Flowjo, GraphPad Prism, BioRender, imaging analysis software and statistical analysis tools; ability to interpret complex immunological data and drive scientific conclusions.
• Leadership: Demonstrated experience leading projects and managing direct reports in a matrixed environment.
• Communication: Excellent written and oral communication skills, with a strong record of technical reports, scientific publications and presentations in English.
• Problem-Solving: Strong troubleshooting skills for experimental and assay-related challenges, with a proactive and results-driven approach to research.
• Desire to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals and with a can-do attitude.
• A passion for science and demonstrated enthusiasm and drive to achieve company goals; adaptability and ability to thrive in a fast-paced environment.
• Experience supporting immuno-oncology, autoimmune disease, or inflammatory disease therapeutic development programs.
• Experience with clinical sample analysis and clinical PD biomarker development.
• Publication record in peer-reviewed immunology or pharmaceutical research journals.
• Experience leading cross-functional R&D teams and managing external research collaborations.
• Hands on lab-based experience in Incucyte live cell analysis and FACS sorting
• Proficiency in maintaining accurate and up-to-date experimental records in ELN and LIMS system in daily lab operations and data reporting.
• Establish strong working relationships with CRO partners in order to collaborate and foster information exchange and to enable efficient execution of work packages
• Experience with in vivo disease models of immunology, inflammation and fibrosis.
• Understanding of the clinical landscape for autoimmune disease treatments (e.g., immune checkpoint, depletion and cytokine blockade pathways).
1. Drug Screening and Evaluation: Responsible for designing and conducting drug screening experiments, evaluating the biological activity, pharmacokinetics, and pharmacodynamics of candidate drugs, providing scientific basis for drug development.
2. Mechanism Research: Focus on disease-related biology and target molecular mechanisms, carry out functional validation and signal pathway analysis, providing theoretical basis and experimental support for candidate drug optimization and target selection.
3. Experimental Design and Execution: Independently design experimental plans according to research objectives, ensuring the rationality and feasibility of experiments; strictly follow experimental operating procedures to ensure the accuracy and reliability of data.
4. Data Analysis and Report Writing: Use statistical software to organize and analyze experimental data, write research reports and technical documents, clearly explaining research results and their significance.
5. Team Collaboration and Communication: Work closely with cross-departmental teams, participate in project discussions, share research results, and jointly promote project progress; maintain academic exchanges with domestic and international peers, and keep track of the latest developments in the field.
1. PhD in cell/molecular biology or immunology and >2 years of relevant experience in an industry setting or MS in the same field with > 5 years of industrial experience.
2. Familiar with in vitro pharmacology and efficacy research methods in new drug development (tumor cell culture, primary cell culture, cell proliferation, apoptosis, cytokine release, multicolor flow cytometry, ADCC, CDC, ADCP, ELISA, ELISPOT, etc.) and able to independently perform the above experiments to complete assigned experimental projects;
3. Have a good understanding of therapeutic macromolecules, including monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, etc., and be familiar with relevant regulations, guidelines, and technical manuals for new drug development.
4. Excellent laboratory, record-keeping, data analysis, and critical thinking skills.
5. Ability to plan, execute, and troubleshoot experiments.
6. Ability to manage multiple projects at any given time and to work successfully in a cross-functional and highly collaborative team environment.
7. The ability of fluent in English communication is desired.
We are seeking a highly experienced and scientifically driven Project Leader in Immunology (Associate Director or Director level) to lead discovery and early development efforts leveraging human primary cell–based in vitro functional assays to advance therapeutic antibody programs targeting autoimmune, inflammatory, and fibrotic diseases.
This role will serve as a key scientific and strategic leader, responsible for driving translational immunology efforts, integrating assay data into decision-making, and influencing target validation, lead optimization, and candidate selection. The individual will collaborate cross-functionally with antibody discovery/engineering, biology, in vivo pharmacology, translational sciences, and clinical teams.
Scientific Leadership
• Lead and shape immunology strategy for therapeutic antibody programs focused on autoimmune, inflammatory, and fibrotic diseases.
• Design, oversee, and interpret in vitro functional assays using human primary immune and non-immune cells (e.g., T cells, B cells, monocytes, dendritic cells, macrophages, ILCs, stromal cells, fibroblasts, and epithelial cells etc.).
• Establish disease-relevant assay systems to assess:
o Mechanism of action (MoA)
o Gene modification of downstream pathways
o Cell activation, differentiation, and signaling
o Cytokine production and immune modulation
o Epithelium-related pathways (e.g. TGF-β signaling, EMT, barrier dysfunction & damage)
o Fibrosis-related pathways (e.g., fibroblast activation, ECM deposition)
• Demonstrate robust inhibition of key disease-relevant pathways.
• Drive target validation, target engagement (e.g. receptor occupancy) and translational biomarker strategies using human-relevant in vitro cell culture models.
• Lead external (e.g. MNC collaboration) and internal programs
• Serve as project team leader or key functional representative for antibody discovery projects.
• Define and execute project strategy, timelines, and milestones from target validation through PCC nomination.
• Integrate data across disciplines (e.g., in vitro pharmacology, in vivo models, PK/PD, biomarker data).
• Present project updates, risks, and strategy to senior leadership and governance committees in English.
• Build and optimize robust, reproducible in vitro primary cell-based assays to support screening and characterization of antibody candidates.
• Apply advanced techniques (e.g., multi-color flow cytometry, multiplex cytokine analysis, molecular biology, and imaging etc.).
• Drive adoption of human-relevant and disease-relevant models, including co-culture systems and 3D models.
• Ensure assay scalability and readiness for lead characterization and optimization workflows.
• Establish and standardize SOPs for immunology and PD assays to ensure data accuracy, reproducibility, and lab efficiency
• Partner with:
o Antibody discovery/engineering for optimization of antibody properties
o In vivo pharmacology to connect in vitro findings to efficacy models
o Translational sciences to align biomarkers and clinical strategy
o Clinical teams to inform first-in-human strategies
• Help to establish PK/PD-efficacy relationships and enable human efficacious dose projection
• Support to identify and transfer clinical biomarker assays to the Clinical Biomarker group
• Establish strong working relationships with CRO partners in order to collaborate and foster information exchange and to enable efficient execution of work packages
• Contribute to regulatory documentation and IND-enabling packages as needed
• PhD degree in Immunology, Molecular Immunology, Cellular Immunology, or a closely related biomedical science discipline, with formal specialized training in immunology.
Professional experience
• Associate Director: ~6–8+ years postdoctoral working experience in biotech, pharmaceutical, or related life sciences industry, with proven track record in immunology research and assay development.
• Director: ~8–16+ years with demonstrated leadership of discovery-stage programs in biotech, pharmaceutical, or related life sciences industry.
Scientific Expertise
• Deep expertise in immunology and immune-mediated diseases, such as:
o Autoimmune disorders (e.g., RA, SLE, IBD)
o Chronic inflammation (e.g., COPD)
o Fibrotic diseases (e.g., pulmonary fibrosis)
• Strong experience with:
o Human primary cell biology for immune and non-immune cells
o Functional immunoassays (e.g., activation, suppression, proliferation, differentiation, killing, and cytokine readouts)
o Translational immunology approaches
• Experience in therapeutic antibody discovery/development such as mAb, BpAb, BsAb, TsAb, and related modalities including TCE, in vivo CAR-T, AOC is highly preferred.
• Prior experience in biotech or pharmaceutical R&D environments
• Understanding of fibrosis biology and stromal-immune interactions
• Experience leading cross-functional R&D teams and managing external research collaborations
• Advanced technical proficiency in:
o Flow cytometry: multi-color panel design, instrument operation for both conventional and spectral flow cytometer, data acquisition, high-dimensional cell phenotyping, and functional cell analysis for diverse primary immune and non-immune cell populations.
o Immune and non-immune cell profiling using a range of other techniques including, ELISA, MSD, Luminex, confocal microscopy, Western Blot, PCR/RT-PCR, ELISpot/FluoroSpot and Incucyte etc.
o All stages of pharmacodynamic (PD) assay development, optimization, validation, and data analysis for preclinical and clinical research.
o Primary lymphoid and myeloid immune cell subset isolation/purification using positive and negative selection strategies, culture, stimulation, and functional characterization from human and animal samples.
o Design, development, validation and implementation of complicated co-culture suppression and killing assays in 2D or 3D in vitro cellular model systems using primary immune/non-immune cells and immortal cell lines under sterile conditions.
o Development, evaluation and implementation of new technologies as required by the projects.
o Proven aseptic technique, attention to detail and acts independently to determine methods and procedures on new or special assignments.
o Multi-omics approaches (preferred)
o Data analysis and interpretation tools: FlowJo, GraphPad Prism, Image J, BioRender, AI, EndNote, ELN and LIMS.
• Scientific Knowledge: Deep and up-to-date scientific knowledge of cellular and molecular immunology, immune system regulation, immune cell function, and therapeutic modulation of immune responses.
• Data & Analytical Skills: Strong quantitative data analysis skills, experience with flow cytometry analysis software and statistical analysis tools; ability to interpret complex immunological data and drive scientific conclusions.
• Communication Skills: Excellent written and verbal communication skills, with the ability to clearly present scientific data, write technical reports, and collaborate effectively across cross-functional teams in English.
• Problem-Solving: Strong troubleshooting skills for experimental and assay-related challenges, with a proactive and results-driven approach to research.
• Desire to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals and with a can-do attitude.
• A passion for science and demonstrated enthusiasm and drive to achieve company goals; adaptability and ability to thrive in a fast-paced environment.
• Proven ability to lead cross-functional project teams.
• Strong strategic thinking and problem-solving skills.
• Excellent communication and presentation abilities in English.
• Track record of impactful scientific contributions (publications, patents, or pipeline advancement).
• Experience in antibody discovery and engineering and delivery of antibody and antibody-based modality programs to PCC stage
• Experience with clinical sample analysis and clinical PD biomarker development
• Publication record in peer-reviewed immunology or pharmaceutical research journals.
• Experience transitioning programs from discovery into IND-enabling stages.
• Demonstrated ability to influence portfolio decisions.
• Ability to translate in vitro human biology into actionable drug development insights.
• Strong balance of hands-on science and strategic leadership.
• Commitment to innovation and scientific excellence.
• Experience of both matrix and line management responsibility.
• Direct contribution to advancing next-generation antibody therapeutics addressing significant unmet medical needs in autoimmune, inflammatory, and fibrotic diseases.
• Experience with in vivo disease models of immunology, inflammation and fibrosis.
• Understanding of the clinical landscape for autoimmune disease treatments (e.g., immune checkpoint, depletion and cytokine blockade pathways).
Scientific Leadership
• Lead and oversee in vivo pharmacology programs supporting antibody discovery and development in immunology (e.g., autoimmunity, inflammation, fibrosis and immune modulation).
• Design and implement robust animal models to evaluate efficacy, PK, target engagement (eg, receptor occupancy), PD, and mechanism of action.
• Drive translational strategies linking preclinical data to clinical endpoints, including biomarker identification and patient stratification.
• Provide scientific direction on dose selection, MoA validation, and differentiation strategies.
Translational Science & Biomarkers
• Establish and lead translational frameworks to bridge preclinical and clinical development.
• Identify and validate predictive biomarkers, pharmacodynamic markers, and translational endpoints.
• Collaborate with clinical and biomarker teams to support first-in-human (FIH) and early clinical studies.
Program Leadership
• Serve as a core member of project teams, influencing strategy, timelines, and decision-making.
• Contribute to target selection, candidate optimization, PCC nomination and IND-enabling studies.
• Develop and present clear data packages for governance committees and external stakeholders.
Cross-Functional Collaboration
• Partner closely with:
o Discovery biology & antibody engineering
o DMPK, toxicology, and bioanalytical teams
o Clinical development and regulatory groups
• Ensure seamless integration across R&D functions to accelerate pipeline progression.
External Engagement
• Manage and oversee CRO services, collaborations and academic partnerships.
• Stay at the forefront of emerging immunology and antibody technologies, incorporating innovation into programs.
• Support and ensure delivery of key programs with MNCs and other strategic partnerships.
Education
• Ph.D. or equivalent in Immunology, Pharmacology, Biomedical Sciences, or related discipline.
Experience
• Director: ~10–15+ years within industry/biotech/biopharma for drug discovery
• Senior Director: ~15–20+ years within industry/biotech/biopharma for drug discovery
• Significant experience in development of therapeutic antibody and antibody-based modalities (biologics preferred).
Scientific Expertise
• Strong background in immunology and inflammatory disease biology in TA such as GI, respiratory, rheumatological and fibrotic diseases etc.
• Extensive hands-on experience with in vivo disease model design, workflow, setup, assessment, optimization and troubleshooting to provide robust readouts for measuring target immunology (e.g., TDAR, GvHD, AD, EAE, CIA/CAIA, Colitis, Asthma, SLE, COPD, and IPF etc.).
• Expert in humanized mouse models (NSG/NOG with human PBMC/CD34+ HSC engraftment) and human target knock-in mouse models (eg. Cytokine, receptor, immune checkpoint, and FcR etc.).
• Familiar with antigen-dependent mouse models for biologics testing including but not limited to T-cell transfer, OVA (OT-I/OT-II), TNBS/Oxazolone, AIC, and DTH.
• Extensive experience in working with internal project teams and external CROs to manage projects and deliver in vivo efficacy data packages of lead candidates from therapeutic antibody pipeline.
• Superb skills in attention to details, planning, self-discipline, time management and organisation.
• Experience of quality control and solving technical problems in animal model development to achieve key project objectives and adhere to timelines.
• Ability to read, understand and act on published scientific information and translate this into in vivo experiments to support our projects.
• Adaptability to changing business needs and learning new techniques
• Passionate, flexible, self-driven, dedicated, inclusive, open-minded, collaborative and forward-thinking.
• Ability to work independently, yet co-operatively with others in a dynamic fast paced environment; genuine desire to be a part of a team and contribute to organizational and team goals
• Deep understanding of:
o PK/PD (rodent and Cyno) and exposure-response relationships
o Translational science principles
o Biomarker development and validation
• Proven success advancing programs into clinical development (IND/CTA).
Leadership & Collaboration
• Demonstrated ability to lead cross-functional teams and influence decision-making.
• Experience managing scientific teams and external partners in a matrix environment.
• Strong communication skills in English with the ability to present complex data clearly to senior leadership and external stakeholders.
Preferred Qualifications
• Experience with immune-modulating biologics (e.g., checkpoint modulators, cytokine/receptor targeting antibodies, bi-specifics and multi-specifics).
• Knowledge of humanized models, translational PK/PD modeling, or systems immunology approaches.
• Track record of publications/patents in immunology or translational pharmacology.
• Experience contributing to regulatory filings (IND, IB, briefing documents).
Success Profile
• Strategic thinker who connects biology, pharmacology, and clinical relevance.
• Data-driven decision maker with strong scientific rigor.
• Collaborative leader with a hands-on mindset when needed.
• Passionate about translating scientific discoveries into impactful therapies for patients.
• Therapeutic focus (e.g., autoimmunity, chronic inflammation, and fibrosis)
• Modalities (e.g., mAb, BsAb, BpAb, TsAb, TCE, in vivo CAR-T, and Fc engineering)
• Geographic scope or global responsibilities
• Matrix and line management responsibility
We are seeking a highly accomplished and motivated Principal Scientist with a PhD in Immunology to lead and drive immunology-focused research, assay development, and immune cell characterization initiatives within our R&D team. The ideal candidate brings rigorous academic immunology training combined with a minimum of 6 years of progressive professional working experience in biotech/pharmaceutical industry, with specialized expertise in flow cytometry-based immune cell profiling, primary immune cell function and pharmacodynamic (PD) assay development, validation, and implementation. This role will be pivotal in supporting drug discovery, preclinical and clinical development programs, delivering high-quality immunological data to advance therapeutic candidates from early-stage research to clinical development.
1. Design, execute, and troubleshoot complex immunological experiments, analyze large-scale flow cytometry and PD assay data using specialized software and interpret results to generate data-driven scientific conclusions and actionable recommendations.
2. Apply advanced flow cytometry techniques to perform comprehensive profiling, phenotyping, and functional analysis of various primary immune cell subsets (including T cells, B cells, NK cells, monocytes, macrophages, dendritic cells, granulocytes, and other innate/adaptive immune cell populations) from preclinical animal models, human peripheral blood, and tissues samples.
3. Provide technical mentorship and scientific training to junior scientists, research associates, and lab technicians on flow cytometry operations, immune cell isolation/handling, and PD assay methodologies; establish and standardize SOPs for immunology assays to ensure data accuracy, reproducibility, and lab efficiency.
4. Collaborate cross-functionally with drug discovery, preclinical development, clinical research, analytical development, and regulatory teams to align immunology strategies with overall program milestones, and support study design for preclinical and clinical trials.
5. Prepare detailed scientific reports, study protocols, and regulatory documentation; present research findings to internal leadership, cross-functional teams, and external partners; contribute to scientific publications, conference presentations, and patent applications.
1. Educational Background: PhD degree in Immunology, Molecular Immunology, Cellular Immunology, or a closely related biomedical science discipline, with formal specialized training in immunology.
2. Industry Experience: A minimum of 6 years of full-time professional working experience in biotech, pharmaceutical, or related life sciences industry, with proven track record in immunology research and assay development.
3. Technical Expertise:
o Advanced proficiency in flow cytometry: multi-color panel design, instrument operation for both conventional and spectral flow cytometer, data acquisition, high-dimensional immune cell phenotyping, and functional immune cell analysis for diverse primary immune cell populations.
o Immune cell profiling using a range of other techniques including ELISpot, ELISA, MSD, Western Blot and PCR.
o Extensive experience in all stages of pharmacodynamic (PD) assay development, optimization, validation, and data analysis for preclinical and clinical research.
o Hands-on experience in primary lymphoid and myeloid immune cell subset isolation/purification using positive and negative selection strategies, culture, stimulation, and functional characterization from human and animal samples.
o Design, develop, validate and implement complicated co-culture suppression and killing assays in 2D or 3D in vitro cellular model systems using primary immune cells and immortal cell lines under sterile conditions.
o Development, evaluation and implementation of new technologies as required by the projects.
o Proven aseptic technique, attention to detail and acts independently to determine methods and procedures on new or special assignments.
4. Scientific Knowledge: Deep and up-to-date scientific knowledge of cellular and molecular immunology, immune system regulation, immune cell function, and therapeutic modulation of immune responses.
5. Data & Analytical Skills: Strong quantitative data analysis skills, experience with flow cytometry analysis software and statistical analysis tools; ability to interpret complex immunological data and drive scientific conclusions.
6. Communication Skills: Excellent written and verbal communication skills, with the ability to clearly present scientific data, write technical reports, and collaborate effectively across cross-functional teams in English.
7. Problem-Solving: Strong troubleshooting skills for experimental and assay-related challenges, with a proactive and results-driven approach to research.
8. Desire to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals and with a can-do attitude.
9. A passion for science and demonstrated enthusiasm and drive to achieve company goals; adaptability and ability to thrive in a fast-paced environment.
• Experience supporting immuno-oncology, autoimmune disease, or inflammatory disease therapeutic development programs.
• Experience with clinical sample analysis and clinical PD biomarker development.
• Publication record in peer-reviewed immunology or pharmaceutical research journals.
• Experience leading cross-functional R&D teams and managing external research collaborations.
• Hands on lab-based experience in Incucyte live cell analysis, confocal microscopy and FACS sorting.
• Proficiency in maintaining accurate and up-to-date experimental records in ELN and LIMS system in daily lab operations and data reporting.
• Establish strong working relationships with CRO partners in order to collaborate and foster information exchange and to enable efficient execution of work packages.
• Experience working with antibody-based therapeutics, and knowledge of antibody mediated functions
This is an outstanding opportunity for a proactive and enthusiastic scientist with
experience to join our Immunology team in an innovative biotech to work closely
with cross-functional teams both internally and externally. We are looking for a highly collaborative immunologist with a passion and motivation for science who ideally has a background and special focus in immune regulation in the context of
autoimmunity and/or inflammation with experience in assay development in vitro and share our vision to bring new therapies to patients in need.
The successful candidate will work closely with project leads within the R&D team to define and implement the immunoassay cascade that model the target biology and that are suitable for profiling and assessing antibodies for activity and mechanism of action and for addressing key questions of target validation and translation.
This is a hands-on lab based role requiring design and set up of immune cell biology
assays and models to support our exciting projects.
• You will utilise your immunological expertise and track-record in immunology to drive forward the science of our early-stage projects.
• Design, set up and run in vitro assays supporting immunology validation, antibody profiling/mechanism of action for our drug discovery programmes.
• Build a strong understanding of the target biology and assays used in the literature and implement suitable assays as part of the project team.
• Work collaboratively with other discovery teams within the company, for example antibody discovery and assay teams as well as project leaders and managers to advance the projects.
• Presentation of work at internal meetings.
• Independently generate, analyse and record high quality data relating to our projects.
• Contribute to project presentations and preparation of materials for meetings and reviews.
• Document experimental work in electronic lab notebook (ELN) and a laboratory information management system (LIMS) to timelines and guidelines.
• Work to a high standard and in accordance with our Health and Safety and other policies and procedures.
• Deliver project goals under strict deadlines in a fast-moving and busy workplace.
• Contribute to a collaborative, data driven, work environment with our core values of trust, togetherness and purpose driving innovation and efficiency within the team.
Essential:
• A PhD in immunology or MSc/MRes plus 3+ years of experience, ideally within industry/biotech/drug discovery.
• Hands on experience working with cell culture and aseptic technique including primary and immortalized cells.
• Handling of regulated fresh and biobank material including human blood processing, PBMC isolation and enrichment/purification of primary immune cell subset etc.
• Hands-on immunology experience including working with immune related assays (T cell, B cell and myeloid cells such as monocyte, dendritic cell and macrophage).
• Hands on experience with immune cell based functional assays like ELISA/MSD, conventional/spectral flow cytometry, ELISpot/FluoroSpot, proliferation/suppression, and cell sorting etc.
• Excellent understanding of assay optimisation, validation and troubleshooting to provide robust readouts for measuring target immunology in vitro.
• Superb skills in attention to details, planning, time management and organisation.
• Experience of quality control and solving technical problems in assay development to achieve key project objectives and adhere to timelines.
• Ability to read, understand and act on published scientific information and translate this into experiments to support our projects.
• Adaptability to changing business needs and learning new techniques.
• Excellent communication skills, including report writing and verbal presentations of findings in English.
• Passionate, self-driven, dedicated, inclusive, open-minded, collaborative and forward-thinking.
• Ability to work independently, yet co-operatively with others in a dynamic fast paced environment; genuine desire to be a part of a team and contribute to organizational and team goals.
Strongly desired (but not essential):
• Understanding of basic concepts in antibody discovery and candidate screening in R&D.
• Develop, validate and implement mono and coculture screening assays in 2D systems using primary cells and immortal cell lines.
• Familiarity with biochemical assays like reporter assays.
• Experience in independent panel design, compensation and data analysis using SSM on FlowJo software for multi-color surface, intracellular and intranuclear FACS staining.
• Experience in cellular immunophenotyping and cytokine profiling.
• Hands-on lab-based experience in Incucyte live cell analysis, confocal microscopy and FACS sorting.
• Practical training in immunocytochemistry / immunofluorescence tissue staining.
• Experience in non-immune cells and interaction between immune cells and non-immune cells in in vitro experimental settings.
• Knowledge of immune cell activation and modulation in human and mice is preferred.
None
1. Keeps up with the latest progress in cancer and/or immunology disease therapy. Lead the discovery project and pipeline proposal, validation, execution and decision.
2. Leads biologic drug discovery efforts covering cell target validation, function validation, in vitro/in vivo efficacy, translational biomarkers etc. Coordinates with internal and external cross-functional teams to drive research projects from idea to IND filing. Oversees the progression of immunology and oncology portfolio.
3. Designs, develops, and troubleshoots biological assays and conducts cell-based assays to guide preclinical studies. Analyzes and interprets the data generated. Effective presents of high-quality data and results to project teams.
4. Collaborates with external vendors/partners such as CROs, external imaging and laboratory resources effectively to drive projects forward. Strategically manages resources to meet discovery goals.
5. Guides and trains the junior scientists, motivates the growth of a talented and aspirational team.
Ph.D. degree in Immunology, Oncology, Cell Biology, Pharmacology, Molecular Biology, or a related life science field. Postdoctoral or industry training in cancer immunotherapy or biologic drug discovery is preferred.
Minimum 10 years of relevant experience in biopharmaceutical or biotechnology industry, with at least 5 years of leadership experience in immunology and/or oncology drug discovery .
Proven track record of leading projects that advanced from early discovery to IND filing or beyond in the relevant therapeutic areas.
Hands-on experience in developing and validating cell-based assays, biology mechanism studies, large molecule discovery, translational research and/or in vivo efficacy/PKPD models
Scientific & Strategic Capability: Strong ability to evaluate and recommend novel therapeutic concepts, emerging targets, and innovative technologies in immunology and/or oncology. Demonstrated expertise in translating scientific insights into actionable drug discovery strategies and pipeline decisions.
Capability to lead cross-functional collaborations including managing relationships with CROs.
Collaborative, team-player attitude. Good written and verbal communication skills in English and Chinese..
Capability to motivate fellow team members and work with passion and enthusiasm.
